Glycoprotein G enables HSV-2 neuroinvasion and provides protection as a glycosylated vaccine antigen
“These findings show that the carbohydrate structures on gG-2 are important for HSV-2 neuroinvasion and that immune responses directed against these structures may interfere with this pathogenic mechanism. For Simplexia, this provides further support for the scientific foundation of our genital herpes vaccine approach.”
— Tomas Bergström, Founder of Simplexia
Ebba Könighofer, Carolina Gustafsson, Lindvi Gudmundsdotter, Ekaterina Mirgorodskaya, Jonas Nilsson, Maria Ekblad, Beata Adamiak, Eva Jennische, Stefan Lange, Edward Trybala, Staffan Görander, Tomas Bergström, Jan-Åke Liljeqvist, Rickard Nordén. PLoS Pathog. 2026 Jul 9;22(7):e1014339. eCollection 2026 Jul.
doi: 10.1371/journal.ppat.1014339. PMID: 42424315
